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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Theaflavin 3,3'-digallate, Trastuzumab
Phytochemical Name Theaflavin 3,3'-digallate (PubChem CID: 21146795 )
Anticancer drug Name Trastuzumab (PubChem CID: / )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 452
Ref_1
Pair Name Theaflavin 3,3'-digallate, Trastuzumab
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Biological Phenomena Induction-->Mitosis
Gene Regulation Down-regulation Phosphorylation MISP hsa126353
Down-regulation Expression PLK1 hsa5347
Down-regulation Expression SHCBP1 hsa79801
In Vitro Model NCI-N87 Gastric tubular adenocarcinoma Homo sapiens (Human) CVCL_1603
HGC-27 Gastric carcinoma Homo sapiens (Human) CVCL_1279
MKN45 Gastric adenocarcinoma Homo sapiens (Human) CVCL_0434
AGS Gastric adenocarcinoma Homo sapiens (Human) CVCL_0139
KATO II Down syndrome Homo sapiens (Human) CVCL_M882
Hs 746.T Gastric adenocarcinoma Homo sapiens (Human) CVCL_0333
HEK293T Healthy Homo sapiens (Human) CVCL_0063
SNU-216 Gastric tubular adenocarcinoma Homo sapiens (Human) CVCL_3946
Result These findings suggest an aberrant mitotic HER2-SHCBP1-PLK1 axis underlies trastuzumab sensitivity and offer a new strategy to combat gastric cancer.
03. Reference
No. Title Href
1 Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer. Nat Commun. 2021 May 14;12(1):2812. doi: 10.1038/s41467-021-23053-8. Click
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